“Trehalose Refreshing Mouthwash,” an innovation from the Faculty of Dentistry, Chulalongkorn University, addresses dry mouth problems in older adults and cancer patients

One of the most common oral health problems among older adults is “dry mouth,” affecting more than 80% of the elderly population. This condition can result from multiple causes, including the use of several medications that reduce saliva production as a side effect, as well as in head and neck cancer patients undergoing radiation therapy, which directly affects the salivary glands.

When saliva in the oral cavity is insufficient, patients experience multiple forms of discomfort, including burning sensations, irritation of oral tissues, tooth decay, and an increased risk of oral fungal infections. These complications can significantly reduce overall quality of life.

A new alternative beyond conventional artificial saliva

Although “artificial saliva” products have long been available to help relieve symptoms, they still have important limitations, particularly unpleasant taste and high viscosity, which discourage many patients from using them continuously.

A research team from the Faculty of Dentistry, Chulalongkorn University, led by Prof. Jeerus Sucharitakul, Assoc. Prof. Pornpan Piboonratanakit, Assoc. Prof. Anjalee Vacharaksa, and Assoc. Prof. Sireerat Sooampon, therefore collaborated to develop a new mouthwash formulation using “trehalose” as the main ingredient.

Trehalose: From natural innovation to oral care

Trehalose is a disaccharide composed of two glucose molecules. It has outstanding properties in retaining moisture and protecting cells from oxidative stress, while not causing tooth decay. Previously, trehalose has been widely used in the food industry and as an ingredient in ophthalmic lubricants, giving it a long-established safety profile. This marks the first time in the world that trehalose has been specifically incorporated into a mouthwash formulation to enhance oral moisture.

Research findings demonstrate effectiveness

The study entitled “Trehalose versus carboxymethylcellulose oral spray for relieving radiation-induced xerostomia in head and neck cancer patients: a randomized controlled trial” evaluated the product in head and neck cancer patients experiencing dry mouth following radiation therapy.

The results demonstrated a statistically significant improvement in patients’ Quality of Life Scores. Patients reported increased oral lubrication, reduced burning sensations, and improved ability to perform daily activities closer to normal.

The next step in development

The research team continues to further improve the formulation by adding fluoride to enhance cavity prevention and studying the incorporation of plant extracts to improve flavor and freshness, as well as help reduce inflammation of oral soft tissues — while maintaining its non-cariogenic properties.

Currently, “Trehalose Refreshing Mouthwash” has officially received a petty patent from the Department of Intellectual Property and is ready to serve as a new oral healthcare option for the general public, older adults, and patients requiring special care.