The Faculty of Dentistry, Chulalongkorn University Develops “Nano Oleogel” Innovation to Reduce Oral Inflammation

The Faculty of Dentistry, Chulalongkorn University is advancing new dental innovations in response to the growing number of patients diagnosed with Oral Lichen Planus, a chronic inflammatory condition caused by immune system dysfunction. The disease leads to persistent lesions in the oral mucosa, resulting in pain and a significant impact on patients’ quality of life.

Dr. Pirawish Limlawan, a lecturer in the Department of Oral Medicine, Faculty of Dentistry, and lead researcher, explained that the current standard treatment involves topical corticosteroids, which are effective in controlling symptoms. However, long-term use may cause significant side effects, particularly opportunistic fungal infections in the oral cavity, which are difficult to manage and may further complicate the condition.

To address these limitations, the research team has been exploring safer alternative therapies. One promising candidate is curcumin, a natural compound extracted from turmeric, widely used in Thailand for its anti-inflammatory and antioxidant properties, as well as its high safety profile.

A key challenge, however, lies in delivering curcumin effectively to the target tissues. To overcome this, the team has developed an innovative drug delivery system known as “Curcumin Nano Oleogel,” designed to enhance the penetration and efficacy of curcumin within oral tissues.

This innovation represents a significant advancement in oral medicine research, aiming to expand treatment options, reduce the side effects associated with conventional therapies, and ultimately improve patients’ quality of life in the future.