รศ.ทพญ.ดร.อรนาฎ มาตังคสมบัติ

Assoc. Prof. Oranart Matangkasombut

อาจารย์ประจำภาควิชาจุลชีววิทยา

ทันตแพทย์ผู้เชี่ยวชาญสาขาทันตสาธารณสุข

Qualification

Ph.D. (Biological Sciences in Dental Medicine)Harvard UniversityB.E. 2545
Diplomate, Thai Board of Dental Public HealthThe Dental CouncilB.E. 2560
D.D.S. Class Honors (Dentistry) Chulalongkorn UniversityB.E. 2537

Research of interests

  • Oral Microbiology and oral microbiome in health and diseases
  • Candida: pathogenesis, virulence, interaction with host, drug resistance, novel antifungal agents
  • Molecular biology in yeast (Saccharomyces cerevisiae and Candida albicans): DNA repair and gene expression

Publications

  1. Cefai D., Schneider H., Matangkasombut O., Kang H., Brody J., Rudd C.E.* (1998) CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation. J Immunol,160(5):2223-30
  2. Matangkasombut O., Buratowski R.M., Swilling N., Buratowski S.* (2000) Bromodomain factor1 corresponds to a missing piece of yeast TFIID. Genes.Dev. 14(8):951-6                     
  3. Matangkasombut O., and Buratowski S.* (2003) Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation. Mol. Cell 11(2):353-63
  4. Matangkasombut O., Auty R., Buratowski S.* (2004) Structure and function of the TFIID complex. Adv Protein Chem. 67:67-92.
  5. Matangkasombut O*. (2006) Oral Candidiasis Part I : Clinical Manifestations and Etiology. J Dent Assoc Thai. 56 (1): 52-63
  6. Matangkasombut O*. (2006) Oral Candidiasis Part II : Current therapeutic guidelines. J Dent Assoc Thai. 56 (1): 64-75
  7. Matangkasombut O*., Siraprapa J., and Wongpraparat I. (2006) The development of a PCR-based assay for the detection and identification of Candida in oral samples. CU Dent J. 29(2): 83-94
  8. Cowen L.E., Carpenter A.E., Matangkasombut O., Fink G.R., Lindquist S.* (2006) Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell. 5(12):2184-8
  9. Pitiphat W., Matangkasombut O., Merchant A. (2007) Re: effect of periodontal treatment on serum C-reactive protein levels: a systematic review and meta-analysis. Ioannidou E, Malekzadeh T, Dongari-Bagtzoglou A. (2006;77:1635-1642). J Periodontol. 78(7):1184-5; author reply 1186-7.
  10. Pornthanakasem W., Kongruttanachok N., Phuangphairoj C., Suyarnsestakorn C., Sanghangthum T., Oonsiri S., Ponyeam W., Thanasupawat T., Matangkasombut O., Mutirangura A*. (2008) LINE-1 methylation status of endogenous DNA double-strand breaks. Nucleic Acids Res. 36(11):3667-75, doi:10.1093/nar/gkn261 published online: May 12. [Epub ahead of print]
  11. Samaksamarn T.,  Sutthiboonyapan C., Pipattanagovit P., and Matangkasombut O.* (2008) Antibacterial effect on Enterococcus faecalis of erbium, chromium: yttrium-scandium-gallium-garnet laser irradiation compared to two irrigating solutions in root canals of extracted human teeth. J Dent CU. 31(2): 125-34
  12. Subbalekha K., Pimkhaokham A., Pavasant P., Chindavijak S., Phokaew C., Shuangshoti S., Matangkasombut O., Mutirangura A.* (2009) Detection of LINE-1s hypomethylation in oral rinses of oral squamous cell carcinoma patients. Oral Oncol. Feb;45(2):184-91. Article first published online: 18 Aug 2008.
  13. Matangkasombut O.*, Wattanawaraporn R., Tsuruda K., Ohara M., Sugai M., and Mongkolsuk S. (2010) Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest and caspase-independent death in a Saccharomyces cerevisiae model. Infect. Immun. 78(2), 783-792., doi:10.1128/IAI.00857-09, Article first published online: 7 Dec 2009
  14. Santiwongkarn P., Kachonboon S., Thanyasrisung P. and Matangkasombut O.*. (2012) Prevalence of oral Candida carriage in Thai adolescents. J Investig Clin Dent. Feb;3(1):51-5.doi: 10.1111/j.2041-1626.2011.0089.x Article first published online: 7 Aug 2011
  15. KantaputraP.N.*, Matangkasombut O., and Sripathomsawat W. (2012) Split Hand-Split Foot-Ectodermal Dysplasia and Amelogenesis Imperfecta with a TP63 Mutation.Am J Med Genet A. Jan;158A(1):188-92.doi: 10.1002/ajmg.a.34356. Article first published online: 7 Nov 2011
  16. Thongsroy J., Matangkasombut O.*, Thongnak A., Rattanatanyong P., Jirawatnotai S., and Mutirangura A.* (2013) Replication-Independent Endogenous DNA Double-Strand Breaks in Saccharomyces cerevisiae Model. PLoS One. Aug 19;8(8):e72706. doi: 10.1371/journal.pone.0072706.
  17. Thanyasrisung P., Kesakomol P., Pipattanagovit P., Youngnak-Piboonratanakit P., Pitiphat W., and Matangkasombut O.*. (2014) Oral Candida carriage and immune status in Thai HIV-infected individuals. J Med Microbiol. May;63(Pt 5):753-9 doi: 10.1099/jmm.0.069773-0. Article first published online: 3 Mar 2014
  18. Panjinda R., Matangkasombut O.*, Ampornaramveth R., Subbalekha K. (2014) Antibacterial efficacy of alcohol on dental anesthetic cartridges. CU Dent J. 37(1),59-68
  19. Ittatirut S., Matangkasombut O.*, Thanyasrisung P.* (2014) In-office bleaching gel with 35% hydrogen peroxide enhanced biofilm formation of early colonizing streptococci on human enamel. J Dent. 42(11), 1480-1486. Aug 15. pii: S0300-5712(14)00237-1. doi: 10.1016/j.jdent.2014.08.003.
  20. Saruttichart T., Chantarawaratit P., Leevailoj C., Thanyasrisung P., Pitiphat W., Matangkasombut O.*. (2017) Effectiveness of a motionless ultrasonic toothbrush in reducing plaque and gingival inflammation in patients with fixed orthodontic appliances. Angle Orthod. Vol. 87, No. 2 (March 2017) pp. 279-285 http://dx.doi.org/10.2319/042516-334.1 [Epub ahead of print, Sep 19, 2016].
  21. Wongpraparatana I., Matangkasombut O.*, Thanyasrisung P., Panich M.* (2018) The effect of vital tooth bleaching on surface roughness and streptococcal biofilm formation on direct tooth-colored restorative materials. Oper Dent. Jan/Feb 2018, Vol. 43, No. 1, pp. 51-59 doi: 10.2341/16-366-L  [Epub ahead of print, Oct 4, 2017].
  22. Tsuruda K., Matangkasombut O., Ohara M., Sugai M.* (2018) CdtC-induced processing of membrane-bound CdtA is a crucial step in Aggregatibacter actinomycetemcomitans CDT holotoxin formation. Infect. Immun. Feb 20;86(3). pii: e00731-17. doi: 10.1128/IAI.00731-17. Print 2018 Mar.
  23. Nguyen T.N.Y., Matangkasombut O., Ritprajak P.* (2018) Differential Dendritic Responses to Cell wall Mannan of Candida albicans, Candida parapsilosis and Candida dubliniensis. J Oral Sci. 2018 Dec 27;60(4):557-566. doi: 10.2334/josnusd.17-0426. Epub 2018 Nov 15.
  24. Thanyasrisung P., Vittayaprasit A., Matangkasombut O., Sugai M., Na Nongkai P., Saipia S. and Hoven V.P.* (2018) Separation and detection of mutans streptococci by using magnetic nanoparticles stabilized with a cell wall binding domain-conjugated polymer. Anal Methods, 10, 3332, DOI: 10.1039/c8ay00114f
  25. Chanomethaporn A., Chayasadom A., Wara-aswapati N., Kongwattanakul K., Suwannarong W., Tangwanichgapong K., Sumanonta G., Matangkasombut O., Dasanayake A.P., Pitiphat W.* (2019) Association between Periodontitis and Spontaneous Abortion: A Case-Control Study. J Periodontol. 2019 Apr;90(4):381-390. doi: 10.1002/JPER.18-0174. Epub 2018 Nov 14.
  26. Nguyen T.N.Y., Padungros P., Wongsrisupphakul P., Sa-Ard-Iam N., Mahanonda R., Matangkasombut O., Choo M.K., and Ritprajak P.* (2018) Cell wall mannan of Candida krusei mediates dendritic cell apoptosis and orchestrates Th17 polarization via TLR-2/MyD88-dependent pathway. Sci Rep. Nov 20;8(1):17123. doi: 10.1038/s41598-018-35101-3.
  27. Denmongkholchai S., Katare P., Choochuay S., Thanyasrisung P., Tsuruda K., Sugai M., Mongkolsuk S., and Matangkasombut O.* (2019) Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model. Front Microbiol. 10:890. 26 April 2019 https://doi.org/10.3389/fmicb.2019.00890 (Q1 Microbiology SJR 1.690, rank 29/158)
  28. Tarapan S., Matangkasombut O., Trachootham D., Sattabanasuk V., Talungchit S., Paemuang W., Phonyiam T., Chokchaitam O., Mungkung O.O., Lam-Ubol A.* (2019) Oral Candida colonization in xerostomic post-radiotherapy head and neck cancer patients. Oral Dis. Jul 1.;25 (7), 1798-1808. doi: 10.1111/odi.13151. (Q1 SJR 0.777, rank 40/211)
  29. Matangkasombut O.* and Thanyasrisung P. (2019) Sugar substitutes and their effects on systemic and oral health. J Dent Assoc Thai;69(4):379-397.doi:10.14456/jdat.2019. 46
  30. Namangkalakul W., Benjavongkulchai S., Pochana T., Promchai A., Satitviboon W., Howattanapanich S., Phuprasong R., Ungvijanpunya N., Supakanjanakanti D., Chaitrakoonthong T., Muangsawat S., Thanyasrisung P., and Matangkasombut O.*. (2019) Activity of Chitosan antifungal denture adhesive against common Candida species and Candida albicans adherence on denture base acrylic resin. J Prosthet Dent;123:181.e1-e7. https://doi.org/10.1016/j.prosdent.2019.09.026 (Q1 SJR 1.151, rank 16/211)
  31. Opasawatchai A., Yolwong W., Thuncharoen W., Inrueangsri N., Itsaradisaikul S., Sasisakulporn C., Jotikasthira W., Matangkasombut O., Reamtong O., Manuyakorn W., Songnuan W., Matangkasombut P.* (2020) Novel Salivary Gland Allergens from Tropical Mosquito Species and IgE Reactivity in Allergic Patients.World Allergy Organ J;13(2):100099. https://doi.org/10.1016/j.waojou.2020.100099 (Q1 in Pulmonary and respiratory medicine, SJR 1.14, rank 24/144)
  32. SupotngarmkulA., Panichuttra A.*, RatisoontornC., Nawachinda M.,and Matangkasombut O.* (2020) Antibacterial property of chitosan against E. faecalis standard strain and clinical isolates. Dent Mater J;39(3), 456-463. https://doi.org/10.4012/dmj.2018-343 (Q2 in Dentistry, SJR 0.642)
  33. Homchan A., Sukted J., Mongkolsuk S., Jeruzalmi D., Matangkasombut O.*, Pakotiprapha D.* (2020) Wss1 homolog from Candida albicans and its role in DNA-protein crosslink tolerance [published online ahead of print, 2020 Apr 17]. Mol Microbiol; 114:409–422. https://doi.org/10.1111/mmi.14518 (Q1 in Microbiology, SJR 2.089)
  34. Lam-Ubol A.*, Matangkasombut O., Trachootham D., Tarapan S., Sattabanasuk V., Talungchit S., Paemuang W., Phonyiam T., Chokchaitam O., Mungkung O.O. (2020) Efficacy of gel-based artificial saliva on Candida colonization and saliva properties in xerostomic post-radiotherapy head and neck cancer patients: a randomized controlled trial. Clin Oral Investig (25), 1815–1827. https://doi.org/10.1007/s00784-020-03484-1 (Q1 in Dentistry SJR 1.019, rank 26/211)
  35. Buranarom N., Komin O., Matangkasombut O.* (2020) Hyposalivation, oral health, and Candida colonization in independent dentate elders. PLoS One Nov 25;15(11):e0242832. doi: 10.1371/journal.pone.0242832. eCollection 2020. (Q1 Multidisciplinary, SJR 1.023, rank 10/145)
  36. Srimaneepong V., Thanamee T., Wattanasirmkit K., Muangsawat S., Matangkasombut O.*(2021) Efficacy of low-molecular weight chitosan against Candida albicans biofilm on polymethyl methacrylate resin. Aust Dent J. 2021 Jan 23. 66(3),262-269. doi: 10.1111/adj.12826. online ahead of print (Q1 in Dentistry SJR 0.663, rank 59/211)
  37. Homchan A., Sukted J., Matangkasombut O.*, Pakotiprapha D.* (2021) Emerging roles of Wss1 in the survival of Candida albicans under genotoxic stresses. Curr Genet 67, 99-105. doi: 10.1007/s00294-020-01123-6. (Q1 in Genetics SJR 1.825, rank 61/340)
  38. Jiang CM., Duangthip D.* , Auychai P., Chiba M., Folayan MO., Hamama HHH., Kamnoedboon P., Lyons K., Matangkasombut O., Mathu-Muju K., Mathur VP., Mei ML., Morgan M., Poolthong S., Rahul M., Srinivasan M., Takahashi T., Yaklai S., Zhang S., Zou XC., Chu CH. and Lo ECM. (2021) Changes in oral health policies and guidelines during the COVID-19 pandemic. Front. Oral. Health 2:668444. doi: 10.3389/froh.2021.668444
  39. Poonpanichakul T., Chan-In W, Opasawatchai A, Loison FX., Matangkasombut O, Charoensawan V and Matangkasombut P*. (2021) Innate Lymphoid Cells Activation and Transcriptomic Changes in Response to Human Dengue Infection. Front. Immunol. 12:599805. doi: 10.3389/fimmu.2021.599805 (Q1 Immunology SJR 2.646, rank 27/213)
  40. Denmongkholchai S., Tsuruda K., Sugai M., Mongkolsuk S., and Matangkasombut O.* (2021) Host Chromatin Regulators Required for Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Activity in Saccharomyces cerevisiae Model. Infect. Immun. May 3:IAI.00036-21. doi: 10.1128/IAI.00036-21. Online ahead of print. (Q1 Microbiology SJR 1.581, rank 31/158)
  41. Suparattanapong P, Chankanka O, Matangkasombut O, Govitvattana N*. (2021) Dental caries and associated risk factors in 13-18-month-old infants receiving breast or formula milk feeding: A cross-sectional study.  Int J Paediatr Dent. 2021 Sep 27. doi: 10.1111/ipd.12930. (Q1 in Dentistry (miscellaneous) SJR 1.183, rank 11/141)
  42. Opasawatchai A*, Nguantad S, Sriwilai B, Matangkasombut P, Matangkasombut O, Srisatjaluk R, Charoensawan V*. (2022) Single-Cell Transcriptomic Profiling of Human Dental Pulp in Sound and Carious Teeth: A Pilot Study. Front Dent Med, 05 January 2022, https://doi.org/10.3389/fdmed.2021.806294
  43. Siripaiboonpong N, Matangkasombut O*, Pengcharoen H, Boonchaiyapluk B, Rujiraprasert P, Srithanyarat SS*. (2022) Microbiological Effects of Virgin Coconut Oil Pulling in Comparison with Palm Oil Pulling as an Adjunctive Oral Hygiene Care for Patients with Gingival Inflammation: A Randomized Controlled Clinical Trial. J Indian Soc Periodontol; 26:58-63 (Q3 in Dentistry SJR 0.309, rank 126/203)
  44. Arora JK, Opasawatchai A, Poonpanichkul T, Jiravejchakul N, Sungnak W, DENFREE Thailand, Matangkasombut O, Teichmann SA*, Matangkasombut P*, Charoensawan V*. (2022) Single-cell Temporal Analysis of Natural Dengue Infection Reveals Skin-Homing Lymphocyte Expansion One Day before Defervescence. iScience. doi: https://doi.org/10.1016/ j.isci.2022.104034. (Q1 in Multidisciplinary, SJR 1.592, rank 10/138)
  45. Kongsangdao B, Matangkasombut O, Ratisoontorn C, Navachinda M, Vijintanawan S, Panichuttra A*. (2022) Physical Properties of White Portland Cement with Bismuth Oxide Modified by Chitosan and Calcium Chloride. J Dent Assoc Thai;72(2):418-426
  46. Saengprasittichok N, Sucharitakul J, Matangkasombut O, Prapinjumrune C*. (2022) Effect of fluocinolone acetonide (0.1%) treatment in oral lichen planus patients on salivary lactoferrin levels and Candida colonization: a prospective study. BMC oral health. Mar 4;22(1):58.doi: 10.1186/s12903-022-02096-3. (Q1 in Dentistry (Miscellaneous), SJR 0.790, rank 22/142)
  47. ThipungS, Panichuttra A*, Ratisoontorn C, PimkhaokhamS, Matangkasombut O*. (2022) Prevalence of Enterococcus faecalis and Clinical Characteristics in Teeth Requiring Endodontic Retreatment. J Dent Assoc Thai. J Dent Assoc Thai;72(3):459-466
  48. Leerahakan P, Matangkasombut O, Tarapan S, Lam-ubol A* (2022) Biofilm formation of Candida isolates from xerostomic post-radiotherapy head and neck cancer patients. Arch Oral Bio; 142, https://doi.org/10.1016/j.archoralbio.2022.105495. (Q1 in Dentistry Clarivate)
  49. Thienngern P, Panichuttra A*, Ratisoontorn C, Aumnate C, Matangkasombut O*. (2022) Efficacy of chitosan paste as intracanal medication against Enterococcus faecalis and Candida albicans biofilm compared with calcium hydroxide in an in vitro root canal infection model. BMC oral health. 22:354, https://doi.org/10.1186/s12903-022-02385-x  (Q1 in Dentistry (Miscellaneous), SJR 0.790, rank 22/142)
  50. Thanyasrisung P*, Satitviboon W, Howattanapanich S, Matangkasombut O*. Antifungal drug resistance in oral Candida isolates from HIV-infected and healthy individuals and efficacy of chitosan as an alternative antifungal agent. Archives of Oral Biology, 147, https://doi.org/10.1016/j.archoralbio.2023.105628 (Available online 18 January 2023) (Q1 in Dentistry Clarivate)
  51. Raksakmanut R, Thanyasrisung P, Sritangsirikul S, Kitsahawong K, Seminario AL, Pitiphat W, and Matangkasombut O*. (2023) Prediction of Future Caries in 1-Year-Old Children via Salivary Microbiome. Journal of Dental Research, https://doi.org/10.1177/00220345231152802 (Available online 15 March 2023) (Q1 in Dentistry, SJR 1.787, rank 6/210)
  52. Manphibool C, Matangkasombut O, Chantarangsu S, Chantarawaratit P1* (2023) Effects of blue-light LED toothbrush on reducing dental plaque and gingival inflammation in orthodontic patients with fixed appliances: a crossover randomized controlled trial. BMC oral health.23,293, https://doi.org/10.1186/s12903-023-02977-1   (Q1 in Dentistry (Miscellaneous), SJR 0.790, rank 22/142)
  53. Siripaiboonpong N, Matangkasombut O*, Pengcharoen H, Boonchaiyapluk B, Rujiraprasert P, Chantarangsu S, Srithanyarat SS*. (2023) Clinical effect of virgin coconut oil pulling in comparison with palm oil pulling on gingival health: a crossover randomized clinical controlled trial. Natural and Life Sciences Communications (in press)

* corresponding/co-corresponding author